Bioorthogonal oncolytic-virus nanovesicles combined bio-immunotherapy with CAR-T cells for solid tumors

作者：Guojun Huang, Yiran He, Xiaocong Chen, Ting Yin, Ai-Qing Ma, Lizhen Zhu, Liqi Chen, Ruijing Liang, Pengfei Zhang, Hong Pan, Lintao Cai · 发表于：Biomaterials Science · 年份：2024 · DOI：10.1039/d4bm01305k · 被引用次数：14 · 研究领域：CAR-T cell therapy research、Virus-based gene therapy research、Monoclonal and Polyclonal Antibodies Research

CAR-T cells in tumors. Our data suggest that bioorthogonal OV nanovesicles hold great potential to overcome the limitations of CAR-T cells as monotherapies against solid tumors and, thus, drive the clinical application of combination therapy.