Copper depletion-induced tumor cuproptosis

作者：Min Zhou, Faheem Muhammad, Yihong Zhang, Tong Li, Jiayuan Feng, Jingyuan Zhao, Hui Wei · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d4sc04712e · 被引用次数：13 · 研究领域：Nanoparticle-Based Drug Delivery、Metal-Organic Frameworks: Synthesis and Applications、Drug Transport and Resistance Mechanisms

. We proposed a copper-depleting mechanism primarily linked to the dysfunction of cellular copper-contained enzymes, contrasting with the mechanism of copper accumulation-induced cuproptosis. Furthermore, by modifying the ZnS nanoparticle with a polydopamine shell and a glucose transporter 1 DNAzyme (GD), we developed a multifunctional copper nanoconsumer with strong tumor growth and metastatic inhibition activity, enhancing copper depletion-promoted tumor therapy.