Associations among environmental unpredictability, changes in resting-state functional connectivity, and adolescent psychopathology in the ABCD study

作者：Yumeng Yang, Tianjiao Kong, Feng Ji, Ran Liu, Liang Luo · 发表于：Psychological Medicine · 年份：2024 · DOI：10.1017/s0033291724001855 · 被引用次数：9 · 研究领域：Functional Brain Connectivity Studies、Mental Health Research Topics、Psychosomatic Disorders and Their Treatments

Abstract Background Unpredictability is a core but understudied dimension of adversities and has been receiving increasing attention recently. The effects of unpredictability on psychopathology and the underlying neural mechanisms, however, remain unclear. It is also unknown how unpredictability interacts with other dimensions of adversities in predicting brain development and psychopathology of youth. Methods We applied cluster robust standard errors to examine how unpredictability was associated with the developmental changes in resting-state functional connectivity (rsFC) of large-scale brain networks implicated in psychopathology, as well as the moderating role of deprivation, using data from the Adolescent Brain Cognitive Development (ABCD) study, which included four measurements from baseline (mean ± s.d. age, 119.13 ± 7.51 months; 2815 females) to 3-year follow-up ( N = 5885). Results After controlling for threat, unpredictability was associated with a smaller increase in rsFC within default mode network (DMN) and a smaller decrease in rsFC between cingulo-opercular network (CON) and DMN. Neighborhood educational deprivation moderated the associations between unpredictability and changes in rsFC within DMN and fronto-parietal network (FPN), as well as between CON and DMN. A smaller decrease in rsFC between CON and DMN mediated the association between unpredictability and externalizing problems. Neighborhood educational deprivation moderated the indirect pathway from un...