AAV-regulated Serpine2 overexpression promotes hair cell regeneration

作者：Qiuhan Sun, Fangzhi Tan, Xinlin Wang, Xingliang Gu, Xin Chen, Yicheng Lu, Nianci Li, Xiaoyun Qian, Yinyi Zhou, Ziyu Zhang, Man Wang, Liyan Zhang, Busheng Tong, Jieyu Qi, Renjie Chai · 发表于：Molecular Therapy — Nucleic Acids · 年份：2024 · DOI：10.1016/j.omtn.2024.102396 · 被引用次数：7 · 研究领域：Hearing, Cochlea, Tinnitus, Genetics、Cancer-related molecular mechanisms research、RNA modifications and cancer

overexpression promotes HC regeneration and suggests that the utilization of inner ear progenitor cells in combination with AAVs might be a promising therapeutic target for hearing restoration.