Real-World Pattern-of-Care Analysis of Primary Cutaneous Lymphomas Radiation Therapy Among European Organisation for Research and Treatment of Cancer Members

作者：Khaled Elsayad, Emmanuella Guenova, Béatrice Fournier, C. Fernandes, E. Clementel, Evangelia Papadavid, Marie Beylot Barry, Felix Pavlotsky, Chalid Assaf, Pablo L. Ortiz‐Romero, Vassilis Kouloulias, Adèle de Masson, Stéphane Dalle, P. Clavère, Max Schlaak, Nina Booken, Marion Wobser, Christina Mitteldorf, Barzilai Aviv, V. Mareco, Fernando Gallardo, Reinhard Dummer, Markus W. Groß, Felix Ehret, Andrea Lancia, Bartłomiej Tomasik, Lorna Hawley, Vincent Rermouchamps, Mona A. Ibrahim, Ahmed Gawish, Mohamed Abouegylah, Martin Stuschke, Adinda Baten, Hans Theodor Eich, Lena Specht, Mario Levis, Stephen Morris, Belinda A. Campbell, Jan P. Nicolay, Richard Cowan, Dora Correia · 发表于：International Journal of Radiation Oncology*Biology*Physics · 年份：2024 · DOI：10.1016/j.ijrobp.2024.11.011 · 被引用次数：9 · 研究领域：Cutaneous lymphoproliferative disorders research、Lymphoma Diagnosis and Treatment、Nonmelanoma Skin Cancer Studies

PURPOSE: We aim to determine the current treatment patterns and recommendations among physicians for cutaneous lymphomas and to identify the types of skin lymphomas for which existing radiation regimens need improvement. METHODS AND MATERIALS: A questionnaire from the European Organisation for Research and Treatment of Cancer was distributed to all members of the Cutaneous Lymphoma Tumour Group and Radiation Oncology Scientific Council. This online survey included 13 questions regarding treatment practices for patients with cutaneous lymphoma. The survey was conducted from August 21 to December 18, 2023. Frequency distributions and subgroup comparisons were calculated and analyzed. RESULTS: We collected 51 completed questionnaires from investigators from 19 countries specializing in cutaneous lymphoma treatment. Radiation doses varied significantly (range, 4-60 Gy). Based on the histologic entity, up to one-third of the investigators delivered hypofractionated regimens (range, 14%-35%). Reduced-dose radiation therapy (RT) was considered by 27% to 63% of investigators. Meanwhile, 18 (35%) investigators considered adapting the radiation dose to the response to immunochemotherapy when treating primary cutaneous diffuse large B cell lymphoma-leg type. Regarding total skin electron beam therapy, 91% of centers delivered reduced-dose regimens, and 18% of investigators applied ultrahypofractionated protocols. CONCLUSIONS: RT in patients with cutaneous lymphoma is highly heterogeneou...