WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study

作者：Charles DeCarli, Kumar B. Rajan, Lee‐Way Jin, Jason D. Hinman, David K. Johnson, Danielle Harvey, Myriam Fornage, Alexa Beiser, Héctor Alfredo Baptista González, Walter A. Kukull, Lisa Barnes, Fanny M. Elahi, Kumar B. Rajan, Raina Croff, Joel H. Kramer, Johannes Weickenmeier, Dana Tudorascu, Marilyn Albert, Suzanne Craft, Gregory A. Jicha, S. J. Wolk, Henry L. Paulson, James B. Brewer, Sanjay Asthana, Sudha Seshadri, Adam M. Brickman, Helena Chui, Amy Nelson, Sean I. Savitz, Andrew J. Saykin, David Geldmacher, Arjun V. Masurkar, Tatjana Rundek, Pauline Maillard, Alex Knaack · 发表于：Stroke · 年份：2024 · DOI：10.1161/strokeaha.124.045903 · 被引用次数：14 · 研究领域：Dementia and Cognitive Impairment Research、Acute Ischemic Stroke Management、Cerebrovascular and Carotid Artery Diseases

As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Moreover, current US demographics indicate that ≈50% of these individuals will be from diverse backgrounds by 2060. Racial and ethnic minority populations bear a disproportionate burden of vascular risk factors magnifying dementia risk. Despite established associations between white matter hyperintensities and cognitive impairment, including dementia, no study has comprehensively and prospectively examined the impact of individual and combined magnetic resonance imaging measures of white matter injury, their risk factors, and comorbidities on cognitive performance among a diverse, nondemented, stroke-free population with cognitive complaints over an extended period of observation. The Diverse VCID (Diverse Vascular Cognitive Impairment and Dementia) study is designed to fill this knowledge gap through 3 assessments of clinical, behavioral, and risk factors; neurocognitive and magnetic resonance imaging measures; fluid biomarkers of Alzheimer disease, vascular inflammation, angiogenesis, and endothelial dysfunction; and measures of genetic risk collected prospectively over a minimum of 3 years in a cohort of 2250 individuals evenly distributed among Americans of Black/African, Latino/Hispanic, and ...