Pharmacological activation of aldehyde dehydrogenase 2 inhibits ferroptosis via SLC7A11/GPX4 axis to reduce kidney stone formation

作者：Jingdong Zhang, Rui Wang, Linguo Xie, Haotian Ren, Di Luo, Yang Yu, Haijie Xie, Zhiqun Shang, Chunyu Liu · 发表于：European Journal of Pharmacology · 年份：2024 · DOI：10.1016/j.ejphar.2024.177132 · 被引用次数：13 · 研究领域：Ferroptosis and cancer prognosis、Caveolin-1 and cellular processes、Ion Transport and Channel Regulation

levels. These collective effects attenuated crystal-induced ferroptosis. However, the renoprotective effects of Alda-1 were inhibited by SLC7A11 siRNA. In conclusion, our study explores the applications of Alda-1 and highlights the potential of targeting ALDH2 as a promising therapeutical strategy for urolithiasis.