Simplified Medication Adherence Questionnaire (SMAQ) for People Living With HIV in a National Hospital in Mexico: Instrument Validation Study

作者：Luis Eduardo Del Moral Trinidad, Luz Alicia González-Hernández, Jaime Andrade‐Villanueva, Pedro Martínez-Ayala, A Rodríguez, Vida Veronica Ruíz Herrera, José Adán Vizcaíno Résendiz, Melva Guadalupe Herrera-Godina, Sérgio Domínguez-Lara · 发表于：Interactive Journal of Medical Research · 年份：2024 · DOI：10.2196/59562 · 被引用次数：4 · 研究领域：HIV/AIDS Research and Interventions、HIV-related health complications and treatments、Biological Research and Disease Studies

BACKGROUND: Adherence to antiretroviral therapy is a critical component in achieving viral suppression in people living with HIV in addition to increasing overall quality of life. Several indirect methods have been used to measure adherence including the Simplified Medication Adherence Questionnaire (SMAQ). OBJECTIVE: The objective of this study is to evaluate the reliability and validity of the SMAQ in men living with HIV/AIDS attending a Mexican national hospital. METHODS: A cross-sectional analytical design study was carried out in a Mexican National Hospital in Jalisco, including men aged >18 years with at least 3 months of antiretroviral treatment, excluding those with cognitive difficulties in answering the survey. A minimum sample size was calculated to detect the contribution of the variables within the model. The analysis included descriptive tests, confirmatory factor analysis, reliability and validity assessment, correlation between adherence and viral load, and association between viral load and adherence. RESULTS: The final analysis included a total of 260 patients with a mean age of 43 (SD 12) years and an average of 8.97 (SD 6.33) years on antiretroviral treatment. The SMAQ showed sufficient structural validity (comparative fit index=1, root-mean-square error of approximation=0, 90% CI 0-0.085) with satisfactory factor loadings on most questions except item 2 (Do you always take your medication at the prescribed time?). The reliability of the scale is acceptabl...