Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice

作者：Lin Yang, Mengdi Zhang, Yuan Zhou, Dongxiao Jiang, Lan Yu, Lingyu Xu, Fan Fei, Wenkai Lin, Yanrong Zheng, Jing Wu, Yi Wang, Zhong Chen · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-54347-2 · 被引用次数：5 · 研究领域：Zebrafish Biomedical Research Applications、Neuroendocrine regulation and behavior、Circadian rhythm and melatonin

The locomotive action involves diverse coordination, necessitating the integration of multiple motor neural circuits. However, the precise circuitry mechanism governing emotion-driven accelerated locomotion remains predominantly elusive. Here we dissect projections from the tuberomammillary nucleus (TMN) to subiculum (SUB) which promote alert-driven accelerated locomotion. We find that TMN histaminergic neurons respond to high-speed locomotion in both natural and alert acceleration. The TMN-SUB circuit is sufficient but not essential for amplifying accelerated locomotion from low to high-speed movement in basal condition, but it is both sufficient and necessary in alert condition for modulating accelerated locomotion during high-speed escape behavior. TMN histaminergic neuron activates SUB glutamatergic "fast locomotor cell" that projects to retrosplenial granular cortex (RSG) mainly through histamine H2 receptor (H2R). This study reveals the critical role of the histamine-tuned SUB circuit in alert-driven accelerated locomotion in mice, providing a theoretical foundation for comprehending neural circuit mechanisms of instinctive behaviors under alert.