Retinoic acid ameliorates rheumatoid arthritis by attenuating inflammation and modulating macrophage polarization through MKP-1/MAPK signaling pathway

作者：Mengyuan Xin, Hangyu Jin, Xiangyu Guo, Liang Zhao, Xiangdan Li, Dongyuan Xu, Long Zheng, Lan Liu · 发表于：Korean Journal of Physiology and Pharmacology · 年份：2024 · DOI：10.4196/kjpp.24.079 · 被引用次数：8 · 研究领域：Cytokine Signaling Pathways and Interactions、interferon and immune responses、Retinoids in leukemia and cellular processes

, we verified that retinoic acid promotes macrophage transition from the M1 to M2 type by upregulating mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) expression and inhibiting P38, JNK and ERK phosphorylation in lipopolysaccharide-stimulated RAW264.7 cells. Notably, the therapeutic effects of retinoic acid were inhibited by MKP-1 knockdown. Retinoic acid exerts a significant therapeutic effect on adjuvant arthritis in mice by regulating macrophage polarization through the MKP-1/MAPK pathway, and play an important role in the treatment of rheumatic diseases.