The association between age at menopause and bone health in Southwest China women: mediation effect of body mass index

作者：Jiayi Chen, Xian Liang, Yanjiao Wang, Dejiquzong, Yuxin Zhang, Liling Chen, Qiaolan Liu, Xing Zhao · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-20628-0 · 被引用次数：6 · 研究领域：Bone health and osteoporosis research、Menopause: Health Impacts and Treatments、Forensic Anthropology and Bioarchaeology Studies

BACKGROUND: Previous studies have yielded inconsistent findings regarding the association between age at menopause and bone health, with limited exploration of potential mediating factors, particularly in the less-developed muti-ethnic regions of China. Our objective was to analyze the association between age at menopause and bone health among postmenopausal women in southwest China, while also examining the mediating effect of body mass index (BMI) and the moderating effect of years since menopause on this association. METHODS AND RESULTS: The analysis included a total of 15,352 naturally postmenopausal women obtained from the baseline data of the China Multi-Ethnic Cohort (CMEC) Study. Multiple linear regression was used for multivariate analysis. Mediation analysis was conducted to examine the mediating role of BMI in the association between age at menopause and bone health. A significant positive association was observed between age at menopause and bone health index (Quantitative ultrasound index, QUI). Specifically, with each year's delay in age at menopause, there was an increase of 0.260 (95% confidence interval (CI): 0.152-0.368) in QUI. Notably, women with later menopause (menopausal age ≥ 53 years) exhibited a higher QUI (β: 2.684, 95%CI: 1.503-3.865). Additionally, BMI partially mediated the relationship between age at menopause and QUI, accounting for 9.0% of the total effect, with an indirect effect coefficient β(95%CI) was 0.023(0.014, 0.032). Besides, it is wo...