Associations of alcohol intake with gut microbiome: a prospective study in a predominantly low-income Black/African American population

作者：Lili Liu, Sang M. Nguyen, Lei Wang, Jiajun Shi, Jirong Long, Qiuyin Cai, Martha J. Shrubsole, Xiao‐Ou Shu, Wei Zheng, Danxia Yu · 发表于：American Journal of Clinical Nutrition · 年份：2024 · DOI：10.1016/j.ajcnut.2024.11.007 · 被引用次数：5 · 研究领域：Gut microbiota and health、Alcohol Consumption and Health Effects、Clostridium difficile and Clostridium perfringens research

BACKGROUND: Alcohol intake can alter gut microbiome, which may subsequently affect human health. However, limited population-based, prospective studies have investigated associations of habitual and recent alcohol intake with the gut microbiome, particularly among Black/African American individuals. OBJECTIVE: We examined the association of alcohol intake with gut microbiome in a predominantly low-income Black/African American population. METHODS: We investigated the dose- and type-specific associations of habitual and recent alcohol intake with the gut microbiome among 538 Black/African American adults (150 males and 388 females). Habitual and recent alcohol intakes were assessed at cohort baseline (2002-2009) and stool collection (2018-2021), respectively. Gut microbiome was profiled using shotgun metagenomic sequencing. Generalized linear models were employed to evaluate the associations between alcohol intakes and gut microbiome composition, with adjustments for sociodemographic characteristics, other lifestyle factors, and comorbidities. False discovery rate (FDR) <0.1 was considered statistically significant. RESULTS: The mean age at enrollment was 53.2 ± 7.7 y, with a mean interval of 13.8 y (range: 9.0-18.1 y) between baseline and stool sample collection. Recent alcohol intake was not significantly associated with microbial taxa abundance. However, habitual alcohol intake, both total amount and types of alcoholic beverages, showed significant associations with several...