Reproducibility and stability of voluntary deep inspiration breath hold and free breath in breast radiotherapy based on real-time 3-dimensional optical surface imaging system

作者：Junxiang Wu, Feng Yang, Jie Li, Xianliang Wang, Ke Yuan, Lipeng Xu, Fan Wu, Bin Tang, L.C. Orlandini · 发表于：Radiation Oncology · 年份：2024 · DOI：10.1186/s13014-024-02549-9 · 被引用次数：6 · 研究领域：Advanced Radiotherapy Techniques、Breast Cancer Treatment Studies、Photodynamic Therapy Research Studies

The aim of this study was to evaluate the inter-fraction reproducibility and intra-fraction stability of breast radiotherapy using voluntary deep-inspiration breath hold (DIBH) and free breathing (FB) based on an optical surface imaging system (OSIS). Seventeen patients (510 breath-hold sessions) treated using a field-in-field (FiF) technique and twenty patients (600 breath-free sessions) treated with a volume-modulated arc therapy (VMAT) technique were included in this retrospective study. All the patients were positioned with the guidance of CBCT and OSIS, and also monitored with OSIS throughout the whole treatment session. Eight setup variations in three directions were extracted from the treatment reports of OSIS for all sessions and were subsequently manually introduced to treatment plans, resulting in a total of 296 perturbed plans. All perturbed plans were recalculated, and the dose volume histograms (DVH) for the target and organs at risk (OAR) were analyzed. The OSIS and CBCT for both DIBH and FB treatments showed a good agreement of less than 0.30 cm in each direction. The intra-fraction respiratory motion data during DIBH were −0.06 ± 0.07 cm, 0.12 ± 0.15 cm, and 0.12 ± 0.12 cm in the lateral, longitudinal, and vertical directions, respectively; for FB, the respiratory motion data were −0.02 ± 0.12 cm, 0.08 ± 0.18 cm, and 0.14 ± 0.20 cm, respectively. For the target, DIBH plans were more sensitive to setup errors; the mean deviations in D 95 for CTV were 39.78 Gy–4...