Neutralization of SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 by human and murine sera

作者：Kun Xu, Yaling An, Xueyuan Liu, Haitang Xie, Dedong Li, Ting Yang, Minrun Duan, Yuanzhuo Wang, Xin Zhao, Lianpan Dai, George F. Gao · 发表于：npj Vaccines · 年份：2024 · DOI：10.1038/s41541-024-01016-6 · 被引用次数：20 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、COVID-19 epidemiological studies

We report SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 neutralizing antibody titers. They displayed increased immune evasion compared to JN.1, especially KP.1 and KP.3, for participants who experienced BF.7/BA.5.2 breakthrough infection or received bivalent (delta/BA.5) vaccine boosting. Second XBB sub-variants breakthrough infection enhanced the neutralization responses. HK.3-JN.1 RBD-heterodimer induced balanced and potent neutralizing responses against recently-circulating SARS-CoV-2 sub-variants in mice, supporting to replace the COVID-19 antigen containing JN.1 or its sub-variants.