Static and Dynamic Functional Network Connectivity in Parkinson's Disease Patients With Postural Instability and Gait Disorder

作者：Bo Shen, Qun Yao, Yixuan Zhang, Yinyin Jiang, Yaxi Wang, Xu Jiang, Yang Zhao, Hai‐Ying Zhang, Shuangshuang Dong, Dongfeng Li, Yaning Chen, Yang Pan, Jun Yan, Feng Han, Shengrong Li, Qi Zhu, Daoqiang Zhang, Li Zhang, Yun‐Cheng Wu · 发表于：CNS Neuroscience & Therapeutics · 年份：2024 · DOI：10.1111/cns.70115 · 被引用次数：6 · 研究领域：Functional Brain Connectivity Studies、Neurological disorders and treatments、Balance, Gait, and Falls Prevention

AIMS: The exact cause of the parkinsonism gait remains uncertain. We first focus on understanding the underlying neurological reasons for these symptoms through the examination of both static functional network connectivity (SFNC) and dynamic functional network connectivity (DFNC). METHODS: We recruited 64 postural instability and gait disorder-dominated Parkinson's disease (PIGD-PD) patients, 31 non-PIGD-PD (nPIGD-PD) patients, and 54 healthy controls (HC) from Nanjing Brain Hospital. The GIFT software identified five distinct independent components: the basal ganglia (BG), cerebellum (CB), sensory networks (SMN), default mode network (DMN), and central executive network (CEN). We conducted a comparison between the SFNC and DFNC of the five networks and analyzed their correlations with postural instability and gait disorder (PIGD) symptoms. RESULTS: Compared with nPIGD-PD patients, the PIGD-PD patients demonstrated reduced connectivity between CEN and DMN while spending less mean dwell time (MDT) in state 4. This is characterized by strong connections. Compared with HC, PIGD-PD patients exhibited enhanced connectivity in the SFNC between CB and CEN, as well as the network between CB and DMN. Patients with PIGD-PD spent more MDT in state 1, which is characterized by few connections, and less MDT in state 4. In state 3, there was an increase in the functional connectivity between the CB and DMN in patients with PIGD-PD. The nPIGD patients showed increased SFNC connectivity bet...