Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis

作者：Zhiwen Liu, Zijing Peng, Yelin Zhong, Jianjun Wu, Sicheng Xiong, Wei Zhong, Jie-Hua Luo, Zhihai Zhang, Hongxing Huang · 发表于：Hereditas · 年份：2024 · DOI：10.1186/s41065-024-00344-w · 被引用次数：3 · 研究领域：Vitamin C and Antioxidants Research、Vitamin K Research Studies、Vitamin D Research Studies

BACKGROUND: The role of vitamin C as an antioxidant in guarding against osteoporosis in adults is still debated. This research employs both a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR) analysis to explore how serum vitamin C levels correlate with the incidence of osteoporosis among adults. METHODS: In this study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2003-2006, and 2017-2018 to conduct both a cross-sectional analysis and MR to investigate the relationship between serum vitamin C levels and the risk of osteoporosis in adults. We adjusted our analyses for essential demographic and lifestyle variables, and applied logistic regression techniques. Genetic determinants of vitamin C levels were analyzed through MR, using methods like inverse-variance weighted (IVW) and MR-Egger to assess causality. Statistical computations were carried out in R, incorporating visual tools such as restricted cubic spline curves (RCS) and forest plots to clarify the dose-response dynamics and variations across different subgroups. This study was approved by the NCHS Ethics Review Board, and informed consent was obtained from all participants. RESULTS: In our investigation, we analyzed data from 3,940 participants, among whom 291 were diagnosed with osteoporosis. The logistic regression analysis of serum vitamin C quartiles did not indicate a significant trend. The most adjusted model showed a sl...