Case report: Successful remission with upadacitinib in a young patient with anti-TNF-refractory intestinal Behçet’s disease

作者：Sumei Sha, Bin Xu, Kairuo Wang, Chenyang Qiao, Haitao Shi, Jiong Jiang, Xiaojing Quan, Xin Liu · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1483993 · 被引用次数：10 · 研究领域：Ocular Diseases and Behçet’s Syndrome、Spondyloarthritis Studies and Treatments、Otitis Media and Relapsing Polychondritis

Background: The limited therapeutic options and inconsistent treatment efficacy of Intestinal Behçet's disease complicate its management, with the absence of standardized guidelines further exacerbating the challenges faced by clinicians. Case Presentation: In this case report, we present a patient with refractory intestinal Behçet's disease who experienced treatment failure with prior biologic agents. This case sheds light on managing this complex scenario with Janus kinase (JAK) inhibitors, the patient achieved mucosal healing after switching to Upadacitinib. Conclusion: This case underscores the potential of Upadacitinib as an effective alternative for managing difficult cases of intestinal Behçet's disease.