Essential tremor plus affects disease prognosis: A longitudinal study

作者：Runcheng He, Mingqiang Li, Xun Zhou, Lanqing Liu, Zhenhua Liu, Qian Xu, Jifeng Guo, Xinxiang Yan, Chunyu Wang, Hainan Zhang, Xinyin Wu, Beisha Tang, Sheng Zeng, Qiying Sun · 发表于：Chinese Medical Journal · 年份：2024 · DOI：10.1097/cm9.0000000000003340 · 被引用次数：4 · 研究领域：Neurological disorders and treatments、Parkinson's Disease Mechanisms and Treatments、Genetic Neurodegenerative Diseases

To the Editor: Essential tremor (ET) is a common movement disorder with significant clinical heterogeneity.[1] Following the proposal of “ET-plus”, the cross-sectional investigation of ET has increased. However, the characteristics of pure ET vs. ET-plus remain unclear. Herein, we present a longitudinal follow-up study of pure ET and ET-plus patients that aimed to clarify disease progression and outcome, to determine the annual incidence rates of pure ET to ET-plus, and ET to Parkinson’s disease (ET-PD), and to investigate the clinical biomarkers influencing disease outcomes. ET patients, diagnosed according to the 2018 International Movement Disorder Society Tremor Group ET diagnostic criteria[2] from May 1, 2021, to April 30, 2022 in Xiangya Hospital, Central South University, were reviewed. The study was registered at ClinicalTrials.gov (No. NCT04198246) and was approved by the Medical Ethics Committee of Xiangya Hospital, Central South University (No. 202105090). Informed consent was obtained from all patients, who were followed up from November 1, 2022, to October 31, 2023. Neurologists performed follow-up evaluations through face-to-face interviews such as hospital visits, community clinic consultations, and home surveys. The diagnosis of ET-PD necessitates satisfying the following three criteria: (1) the diagnosis of PD must adhere to the clinical diagnostic criteria outlined by the International Parkinson and Movement Disorder Society in 2015, and the diagnosis of PD ...