Burden of liver steatosis and liver fibrosis in a large cohort of people living with HIV

作者：Montserrat Laguno, Elisa de Lazzari, Leire Berrocal, Alexy Inciarte, Maria Martínez‐Rebollar, Lorena de la Mora, Berta Torres, Ana Gonzalez‐Cordón, Iván Chivite, Alberto Foncillas, Júlia Calvo, Abiu Sempere, Juan Ambrosioni, José Luís Blanco, José M. Miró, Josep Mallolas, Estebán Martínez · 发表于：HIV Medicine · 年份：2024 · DOI：10.1111/hiv.13730 · 被引用次数：4 · 研究领域：Liver Disease Diagnosis and Treatment、HIV-related health complications and treatments、Hepatitis C virus research

BACKGROUND: Liver steatosis (LS) and liver fibrosis (LF) can increase the risk of cardiovascular disease in people with HIV, but their prevalence and associated factors are poorly understood. This study aimed to assess the prevalence of and factors associated with LS and LF in a large cohort of people with HIV. METHODS: We conducted a cross-sectional study of consecutive people with HIV attending the Clinic of Barcelona from September 2022 to September 2023, excluding those with chronic B or/and C hepatitis virus coinfection. LS was assessed using the Hepatic Steatosis Index (HSI) and Fatty Liver Index (FLI), and LF was assessed using the Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS), Fibrosis-4 score (FIB-4), and the European AIDS Clinical Society (EACS) algorithm in both the whole cohort (cohort 1) and in a specific cohort more susceptible to liver disease (cohort 2). We identified independent variables associated with LS and LF using logistic regression. RESULTS: Cohort 1 included 4664 people with HIV; 76% and 37% of them had available HSI and FLI data, LS was present in 28% and 19%, respectively. LF risk was present in 1%, 2%, and 1% of people with HIV according to NFS, FIB-4, and EACS algorithm scores, respectively. Cohort 2 included 1345 people with HIV; 60% and 30% of them had available HSI and FLI data, LS affected 55% and 43% and LF 2%, 5%, or 3%, respectively. Factors associated with LS included current CD4 cell count, diabetes, and hypertension, whereas LF...