Sarcopenia and frailty among older Chinese adults: Findings from the CHARLS study

作者：Weiwei Xu, Jiasheng Cai, Yichen Liu, Lian Li, Xiaomei Ye, Ping Wang, Jiaping Lu, Mohammed Ahmed Akkaif, Min Zhang · 发表于：PLoS ONE · 年份：2024 · DOI：10.1371/journal.pone.0312879 · 被引用次数：14 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Body Composition Measurement Techniques

BACKGROUND: Sarcopenia and frailty are common among elderly individuals and present substantial health hazards. Exploring their relationship is essential for optimizing geriatric healthcare, particularly within the context of China. METHODS: A population-based cross-sectional design was employed using data from the China Health and Retirement Longitudinal Study (CHARLS). The study enrolled 5,714 participants aged ≥60 years who underwent assessment for sarcopenia following the criteria established by the Asia Working Group for Sarcopenia (AWGS 2019) in 2019. Frailty status was determined using a frailty index that categorized participants into robustness, pre-frailty, and frailty stages. Multivariable logistic regression models were employed to examine the relationship between sarcopenia and frailty and pre-frailty conditions. Subgroup and interaction analyses were performed to explore the robustness of the associations between sarcopenia and frailty across different subgroups. RESULTS: Among the participants, 1,028 (18.0%) were identified as frailty, 2,987 (52.3%) as pre-frailty, and 645 (11.3%) had sarcopenia. Sarcopenia demonstrated an independent association with higher risks of frailty (OR = 2.13, 95% CI: 1.52-2.99) and pre-frailty (OR = 1.42, 95% CI: 1.20-1.81) in the multivariable logistic analysis. Subgroup and interaction analyses consistently demonstrated significant associations across nearly all demographic and health-related subgroups. CONCLUSIONS: This study high...