Convergent and divergent immune aberrations in COVID-19, post-COVID-19-interstitial lung disease, and idiopathic pulmonary fibrosis

作者：Bochra Tourki, Minxue Jia, Τheodoros Karampitsakos, Iset M Vera, Alyssa Arsenault, Zainab Fatima, Carole Y. Perrot, Dylan Allen, Forouzandeh Farsaei, David Rutenberg, Debabrata Bandyopadhyay, Ricardo Restrepo‐Jaramillo, M.R. Qureshi, K. Patel, Αrgyris Τzouvelekis, Maria G. Kapetanaki, Brenda Juan-Guardela, Kami Kim, Panayiotis V. Benos, Jose D. Herazo‐Maya · 发表于：American Journal of Physiology-Cell Physiology · 年份：2024 · DOI：10.1152/ajpcell.00528.2024 · 被引用次数：11 · 研究领域：Medical and Biological Ozone Research、Long-Term Effects of COVID-19、Cancer Immunotherapy and Biomarkers

Changes in the 50-gene signature, reflective of increase in CD14 + HLA-DR low CD163 + monocytes and decrease in CD4 and CD8 T cells, are associated with increased mortality in COVID-19. A reversal of this pattern can be seen in post-COVID-19-ILD, whereas its persistence can be seen in IPF. Modulating the imbalance between HLA-DR low monocytes and T cell subsets should be investigated as a potential strategy to treat pulmonary fibrosis associated with severe COVID-19 and progressive IPF.