Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis (Adv. Sci. 38/2024)

作者：Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Song Huan, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐Yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan · 发表于：Advanced Science · 年份：2024 · DOI：10.1002/advs.202470226 · 被引用次数：11 · 研究领域：Lipid metabolism and disorders、Phagocytosis and Immune Regulation、Cancer, Lipids, and Metabolism

Lysine-Lactylation In article number 2406333, Jian-yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan, and co-workers explore the protein lysine lactylation (Kla) landscape, identifying Kla as a key factor in cancer immunotherapy resistance. The cover illustration depicts a tree resembling human lungs under attack by lactylated proteins crossing the immunotherapy barrier. The authors propose APOC2K70 Ab (Ruyi Jingu Bang) as a potent tool to block this process and enhance sensitivity to immunotherapy.