Systemic immune-inflammation mediates the association between Klotho protein and metabolic syndrome: findings from a large-scale population-based study

作者：Yongzhou Liang, Ying Liu, Qin Tan, Kaiyu Zhou, Yurong Wu, Yu Li · 发表于：Lipids in Health and Disease · 年份：2024 · DOI：10.1186/s12944-024-02339-y · 被引用次数：10 · 研究领域：Parathyroid Disorders and Treatments、Inflammatory Biomarkers in Disease Prognosis、Blood properties and coagulation

BACKGROUND: This study utilized large-scale population data from the National Health and Nutrition Examination Survey (NHANES) to elucidate the relationship between the Klotho protein and metabolic syndrome along with its components. We further investigated the possible mediating effect of inflammation on these relationships. Our objective was to identify biomarkers for risk stratification and potential therapeutic targets for metabolic syndrome. METHODS: This study enrolled 13,119 participants aged 40-79 years, spanning five NHANES cycles from 2007 to 2016, with complete information on metabolic syndrome and the Klotho protein. The definition of metabolic syndrome followed the criteria of the National Cholesterol Education Program-Adult Treatment Panel III. Survey-weighted logistic regression and subgroup analysis were used to explore the associations between serum Klotho protein levels and metabolic syndrome, along with its components. Mediation analysis was performed to investigate the mediating effects of inflammation-related markers, including white blood cells, neutrophils, lymphocytes, monocytes, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) and the monocyte-to-HDL ratio (MHR), with the aim of elucidating how the Klotho protein influences the onset and progression of metabolic syndrome. RESULTS: The study participants had an average age of 56.06 years (95% CI: 55.76-56.37), with a Klotho p...