Blood lipid profiles associated with metastatic sites in advanced gastric cancer

作者：Hui Zhang, Yiming Liam Liu, Feng Li, Long Wang, Jing Han, Xue Zhang, Yu Wang, Dan Dan Li, Jiayin Liu, Yan Liu, Hui Jin, Zhisong Fan · 发表于：BMC Gastroenterology · 年份：2024 · DOI：10.1186/s12876-024-03479-2 · 被引用次数：2 · 研究领域：Cancer, Lipids, and Metabolism、Inflammatory Biomarkers in Disease Prognosis、Lipid metabolism and disorders

BACKGROUND: This study explored the correlation between peripheral blood lipid levels and clinicopathological parameters in patients with advanced gastric cancer (GC), focusing on changes in lipid levels during disease progression. METHODS: Pathological features and serum lipid profiles of 179 patients with stage III-IV gastric adenocarcinoma were analyzed. Lipid parameters examined included total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), apolipoprotein AI (Apo AI), apolipoprotein B (Apo B), lipoprotein(a) (Lp(a)), among others. The total cholesterol-lymphocyte score (TL score) and BMI were also calculated. The association between lipid parameters and clinicopathological characteristics such as age, gender, family history, and metastasis sites was assessed. RESULTS: In GC patients, females had higher TG levels than males. Patients with peritoneal metastasis had significantly lower levels of TC, LDL-C, Apo B, and B/A ratio. Those with lung metastasis exhibited higher LDL-C levels and lower levels of VLDL-C. No significant associations were found between lipid levels and metastasis to distant lymph nodes, liver, or bone. Female patients with ovarian metastasis had significantly lower VLDL-C levels. Multivariate analysis revealed low TC as an independent risk factor for peritoneal metastasis, high LDL-C and low VLDL-C levels for lung metastasi...