The Burden of All-Cause Mortality Following Influenza-Associated Hospitalizations: Influenza Hospitalization Surveillance Network, 2010–2019

作者：Alissa O’Halloran, Alexander J. Millman, Rachel Holstein, Sonja J. Olsen, Charisse N Cummings, Shua J. Chai, Pam Daily Kirley, Nisha B. Alden, Kimberly Yousey‐Hindes, James Meek, Kyle P. Openo, Emily Fawcett, Patricia Ryan, Lauren Leegwater, Justin Henderson, Melissa McMahon, Ruth Lynfield, Kathy M Angeles, Molly Bleecker, Suzanne McGuire, Nancy Spina, Brenda L. Tesini, Maria Gaitán, Krista Lung, Eli Shiltz, Ann Thomas, H. Keipp Talbot, William Schaffner, Mary Hill, Carrie Reed, Shikha Garg · 发表于：Clinical Infectious Diseases · 年份：2024 · DOI：10.1093/cid/ciae547 · 被引用次数：19 · 研究领域：Influenza Virus Research Studies、Respiratory viral infections research、Infectious Encephalopathies and Encephalitis

BACKGROUND: While the estimated number of US influenza-associated deaths is reported annually, detailed data on the epidemiology of influenza-associated deaths, including the burden of in-hospital vs post-hospital discharge deaths, are limited. METHODS: Using data from the 2010-2011 through 2018-2019 seasons from the Influenza Hospitalization Surveillance Network, we linked cases to death certificates to identify patients who died from any cause during their influenza hospital stay or within 30 days post discharge. We described demographic and clinical characteristics of patients who died in the hospital vs post discharge and characterized locations and causes of death (CODs). RESULTS: Among 121 390 cases hospitalized with laboratory-confirmed influenza over 9 seasons, 5.5% died; 76% of deaths were in patients aged ≥65 years, 71% were non-Hispanic White, and 34% had 4 or more underlying medical conditions. Among all patients with an influenza-associated hospitalization who died, 48% of deaths occurred after hospital discharge; the median number of days from discharge to death was 9 (interquartile range, 3-19). Post-discharge deaths more often occurred in older patients and among those with underlying medical conditions. Only 37% of patients who died had "influenza" as a COD on their death certificate. Influenza was more frequently listed as a COD among persons who died in the hospital compared with cardiovascular disease among those who died after discharge. CONCLUSIONS: All-...