Effect of perioperative rehabilitation exercise on postoperative outcomes in patients aged ≥65 years undergoing gastrointestinal surgery: A multicenter randomized controlled trial

作者：Xuecai Lv, Aisheng Hou, Shiyi Han, Jiangbei Cao, Jingsheng Lou, Hao Li, Su Min, Hongyu Tan, Shuo Li, Feng Lv, Zhikang Zhou, Menglin Chi, Hong Zhang, Yanhong Liu, Weidong Mi · 发表于：Journal of Clinical Anesthesia · 年份：2024 · DOI：10.1016/j.jclinane.2024.111670 · 被引用次数：4 · 研究领域：Enhanced Recovery After Surgery、Cardiac, Anesthesia and Surgical Outcomes、Music Therapy and Health

STUDY OBJECTIVES: This study aimed to assess the effect of perioperative rehabilitation exercise, initiated shortly after hospital admission, on postoperative outcomes in elderly patients. DESIGN: A prospective, multicenter, randomized, controlled, open-label, and assessor-blinded clinical trial. SETTING: Hospital wards. PATIENTS: Elderly patients (≥65 years, n = 160) scheduled for gastrointestinal surgery between June 2021 and November 2022 were enrolled and randomly assigned to the intervention or control group. INTERVENTIONS: Patients were divided into two groups base on whether they had received a specific type of exercise program initiated after hospital admission and continued until 30 days after surgery. MEASUREMENTS: The primary outcome was the Comprehensive Complications Index (CCI) measured at 30 days after surgery. Secondary outcomes were the rate of complications, number of complications, patient satisfaction, hospital readmission, postoperative length of stay, gastrointestinal function recovery, postoperative quality of life and psychological status. Intention-to-treat (ITT) and per-protocol (PP) analyses were conducted. MAIN RESULTS: ITT analysis showed a significantly lower 30-day CCI in the intervention group (β: -6.31; 95 % Confidence Interval [CI], -11.26 to -1.37, P = 0.013). Compared to controls, the intervention group had a decreased rate of hospital readmission (Odds Ratio: 0.00; 95 % CI, 0.00 to 0.32, P = 0.022), less number of complications (β: -0.57; ...