Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation

作者：Min Zhu, Yan Fang, Yi-Kang Sun, Shaoyue Li, Jifeng Yu, Bing Xiong, Congjian Wen, Boyang Zhou, Bin Huang, Haohao Yin, Huixiong Xu · 发表于：Advanced Science · 年份：2024 · DOI：10.1002/advs.202407373 · 被引用次数：7 · 研究领域：Ultrasound and Hyperthermia Applications、Microbial Inactivation Methods、Nerve injury and regeneration

Sonogenetics is an innovative technology that integrates ultrasound with genetic editing to precisely modulate cellular activities in a non-invasive manner. This method entails introducing and activating mechanosensitive channels on the cell membrane of specific cells using gene delivery vectors. When exposed to ultrasound, these channels can be manipulated to open or close, thereby impacting cellular functions. Sonogenetics is currently being used extensively in the treatment of various chronic diseases, including Parkinson's disease, vision restoration, and cancer therapy. This paper provides a comprehensive review of key components of sonogenetics and focuses on evaluating its prospects and potential challenges in the treatment of chronic disease.