Review of Microneedle Technology for Targeted Therapeutics in Vitiligo: Design Principles, Application Prospects

作者：Yihui Yu, Wěi Li, Qian Li, Wenyan Liu, Sanquan Zhang, Xibao Zhang, Jingyao Liang · 发表于：Drug Design Development and Therapy · 年份：2024 · DOI：10.2147/dddt.s449381 · 被引用次数：5 · 研究领域：Advancements in Transdermal Drug Delivery、Bee Products Chemical Analysis、melanin and skin pigmentation

Vitiligo is a chronic autoimmune disorder characterized by depigmented patches of the skin. The treatment of vitiligo remains challenging, partly owing to the lack of efficient drug delivery system. Microneedles (MNs), an ideal transdermal drug delivery system, have emerged as promising drug delivery platform for vitiligo. Recently, the emergence of novel MNs with increased biocompatibility, including hydrogel and hollow MNs, further enhance the translational value of MNs in the treatment of vitiligo. However, up-to-date review of these advancements remains lacking. This review aims to summarize the most recent studies of MN-based drug delivery systems for vitiligo, highlighting the translational potential of MNs as a therapeutic platform for the treatment of vitiligo in the near future.