The global dispersal of visceral leishmaniasis occurred within human history

作者：João Luís Reis-Cunha, Cooper Alastair Grace, Sophia Ahmed, Simon Harnqvist, Cian J. Lynch, Mariana Côrtes Boité, Gabrielle Barcellos, Laurence Lachaud, Patrick Bastien, Harry Munt, Jeremy C. Mottram, Elisa Cupolillo, Daniel Jeffares · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2024 · DOI：10.1101/2024.10.30.621037 · 被引用次数：4 · 研究领域：Research on Leishmaniasis Studies

Abstract The Leishmania donovani species complex (LdSC) causes visceral leishmaniasis (VL), is present in Africa, Europe, the Middle East, Asia and the Americas, and causes 20-40,000 fatalities per year. Previous analyses concluded that dispersal of this species complex occurred 1-10 million years ago. Using updated methods and data, we show that a ten-thousand year old East African population dispersed globally only within the last 2,000 years, consistent with human migration, war and colonisation as driving factors.