[ 18 F]AlF-NOTA-pentixather PET/CT of CXCR4 in patients with suspected primary hyperaldosteronism

作者：Limeng He, Yan Yang, Xu Cao, Xianjun Zhu, Nan Liu, Xiaoyuan Chen, Jingjing Zhang, Wei Zhang · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.100848 · 被引用次数：14 · 研究领域：Hormonal Regulation and Hypertension、Estrogen and related hormone effects、ATP Synthase and ATPases Research

Background: Distinguishing unilateral aldosterone-producing adenomas (APA) from idiopathic hyperaldosteronism (IHA), nonfunctional adrenal adenoma (NFA), and pheochromocytoma (PHEO) within primary aldosteronism (PA) presents a significant challenge.Studies have demonstrated high levels of chemokine receptor (CXCR) 4 expression in APA, thereby validating the use of 68 Ga-labeled CXCR4 PET/CT for detecting APA.This study evaluates the efficacy of [ 18 F]AlF-NOTA-pentixather PET/CT in distinguishing APA from other PA types.Methods: In the initial experiment, a comparative analysis was conducted to evaluate the diagnostic efficacy of [ 18 F]AlF-NOTA-T140 PET/CT and [ 18 F]AlF-NOTA-pentixather PET/CT for APA in 3 patients with PA.Based on the preliminary findings, [ 18 F]AlF-NOTA-pentixather PET/CT was subsequently performed on 45 patients with suspected PA and 5 controls.Lesions exhibiting higher tracer uptake than normal adrenal glands were considered positive and referred for adrenalectomy.Prior to surgery, adrenal venous sampling (AVS) was performed in 71.1% of patients to assess laterality.Postoperative follow-up was conducted in 91.1% of patients.The semi-quantitative analysis involved assessing maximum standardized uptake value (SUVmax), LLR (lesion-to-liver ratio), and lesion-to-contralateral ratio (LCR).Correlations were made between PET/CT findings, histopathology results, outcomes, and AVS.Results: In terms of diagnosing APA, [ 18 F]AlF-NOTA-pentixather PET/CT demonstra...