Stem cell–homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling

作者：Fei‐Long Wei, Yuan Zhai, Tian‐Fu Wang, Jingwei Zhao, Chaoli Wang, Zhen Tang, Kuo Shen, Hao Wu, Rui Zheng, Ming‐Rui Du, Wei Heng, Xiaoxiang Li, Xiaodong Yan, Quan-You Gao, Zheng Guo, Jixian Qian, Cheng-Pei Zhou · 发表于：Science Advances · 年份：2024 · DOI：10.1126/sciadv.adq6700 · 被引用次数：75 · 研究领域：Bone Tissue Engineering Materials、Bone fractures and treatments、Bone health and treatments

Osteoporotic bone defects refer to the disruption of bone structural integrity in patients with osteoporosis and pose a substantial challenge to orthopedic surgeons. In this study, we developed a biomimetic hydrogel to improve the osteogenic microenvironment and promote stem cell homing. This hydrogel served as a container for S-nitrosoglutathione and Ca 2+ , promoting the release of bioactive nitric oxide (NO) from bone marrow mesenchymal stem cells (BMSCs) and human vascular endothelial cells and activating the NO/cyclic guanosine monophosphate signaling pathway. These changes promote osteogenic and angiogenic couplings. The hydrogel simultaneously recruited BMSCs by conjugating the stem cell homing peptide SKPPGTSS. Using a rat distal femoral defect model, it was demonstrated that this hydrogel can effectively increase the formation of bone tissue and new blood vessels and has immune-regulating functions. We envision that this hydrogel may be a minimally invasive yet highly effective strategy for expediting the healing of osteoporotic bone defects.