Validation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis

作者：Ludi Zhang, William Rojas‐Carabali, Shannon Sheriel Choo, Zheng Xian Thng, Amanda Yuan Ling Lim, Bernett Lee, S. Jun, Gazal Patnaik, Jyotirmay Biswas, Aniruddha Agarwal, Ilaria Testi, Sarakshi Mahajan, John H. Kempen, Justine R. Smith, Peter McCluskey, Onn Min Kon, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta, Rupesh Agrawal, Collaborative Ocular Tuberculosis Study (COTS) Group, Rupesh Agrawal, Ilaria Testi 2, Sarakshi Mahajan 4, Yew Sen Yuen 5, Aniruddha Agarwal, Andrés Rousselot, Dhananjay Raje 8, Dinesh Visva Gunasekeran, Onn Min Kon 9, Talin Barisani‐Asenbauer, John H. Kempen 11, Amod Gupta 6, Douglas A. Jabs 12, Justine R. Smith, Bahram Bodaghi, Manfred Zierhut, Marc DeSmet 16, Peter McCluskey, Manisha Agarwal, Kanika Aggarwal, Kanika Aggarwal 6, Mukesh Agrawal, Hassan Al-Dhibi, Sofia Androudi, Fatma Asyari 23, Manohar Babu Balasundaram, Kalpana Babu Murthy, Edoardo Baglivo, Alay Banker 27, Reema Bansal 6, Soumyava Basu 28, Digamber Behera, Jyotirmay Biswas, Ester Carreño, Laure Caspers, Soon‐Phaik Chee, Romi Chhabra, Luca Cimino 33, Luz Elena Concha del Río, Emmett T. Cunningham, André Luiz Land Curi, Dipankar Das 37, Ekaterina V. Denisova, Alastair K. Denniston, Marie-Hélène Errera 40, Alejandro Fonollosa 41, Amala George 18, Debra A. Goldstein, Yan Guex Crosier, Avinash Gurbaxani 2, Alessandro Invernizzi, Hazlita Mohd Isa, Shah Md. Islam, Nicholas Jones, Deeksha Katoch 6, Moncef Khairallah, Amit Khosla 48, Michal Kramer 49, Amitabh Kumar, Atul Kumar 51, Rina La Distia Nora, Richard Lee 2, Careen Y. Lowder, Saurabh Luthra 53, Padmamalini Mahendradas, Dorine Makhoul 30, Shahana Mazumdar, Salil Mehta 56, Elisabetta Miserocchi, Manabu Mochizuki, Oli S Mohamed 59, Cristina Muccioli, Marion R Munk 61, Somasheila Murthy 62, Shishir Narain 63, Heloísa Nascimento, Piergiorgio Neri, Myhanh Nguyen 66, Annabelle A. Okada, Pinar Ozdal 68, Alan Palestine 69, Francesco Pichi 65, S R Rathinam 70, Ariel Schlaen 71, Shobha Sehgal, H Nida Sen 72, Kusum Sharma, Kusum Sharma 6, Samir S. Shoughy, Ramandeep Singh, Ramandeep Singh 6, Masoud Soheilian 74, Sudharshan Sridharan, Jennifer E Thorne 75, Christoph Tappeiner, Stephen Teoh 76, Maria Sofia Tognon 77, İlknur Tuğal-Tutkun, Mudit Tyagi 79, Harvey Uy 80, Daniel V. Vasconcelos-Santos, Nataša Vidović Valentinčič, Mark Westcott, Ryoji Yanai 83, Bety Yañez Alvarez, Rahman Zahedur 85, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta 6 · 发表于：JAMA Ophthalmology · 年份：2024 · DOI：10.1001/jamaophthalmol.2024.4567 · 被引用次数：10 · 研究领域：Ocular Diseases and Behçet’s Syndrome、Infectious Diseases and Tuberculosis、Mycobacterium research and diagnosis

Importance: This was the first study, to the authors' knowledge, to statistically evaluate the predictive accuracy of Collaborative Ocular Tuberculosis Study (COTS) calculator in guiding initiation of antitubercular therapy (ATT) in patients with clinically suspicious tubercular uveitis (TBU) in an international cohort. Objective: To evaluate the accuracy of a score of 4 or greater on the online COTS calculator in recommending ATT initiation. Design, Setting, and Participants: This study was an evaluation of a diagnostic test or technology. Data input required for the COTS calculator were extracted from the COTS-1 study dataset, which comprised retrospective, observational records of patients with TBU who were monitored for 12 months after treatment. Patients were recruited from international ophthalmic centers. In the absence of a traditional criterion standard, the 12-month treatment response to ATT was used to classify patients as disease positive or negative. The accuracy of clinicians at the ATT decision-making stage in the COTS-1 study was set against COTS calculator scores of 4 or greater. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value (PPV), precision, recall, and F1 score, were computed. Data collected from January 2004 to December 2014 were analyzed. Exposures: COTS calculator to guide initiation of ATT in patients with TBU. Main Outcomes and Measures: Comparison of accuracy between clinician judgment and the COTS calculat...