Associations of ambient air pollution and daily outpatient visits for pediatric atopic dermatitis in Shanghai, China

作者：Lijuan Liu, Cong Liu, Renjie Chen, Rui Feng, Yufeng Zhou, Libo Wang, Jianguo Hong, Lanfang Cao, Yanming Lu, Xiaoyan Dong, Min Xia, Bo Ding, Liling Qian, Wenhao Zhou, Yonghao Gui, Wen He, Qīng Wáng, Xiao Han, Aizhen Lu, Xiaobo Zhang · 发表于：Ecotoxicology and Environmental Safety · 年份：2024 · DOI：10.1016/j.ecoenv.2024.117231 · 被引用次数：6 · 研究领域：Allergic Rhinitis and Sensitization、Climate Change and Health Impacts、Dermatology and Skin Diseases

Limited evidence was available on ambient air pollution and pediatric atopic dermatitis (AD). The study aimed to evaluate the associations between short-term exposure to air pollutants and outpatient visits for pediatric AD. From 2016–2018, we collected data on six criteria air pollutants (PM 2.5 , PM 10 , NO 2 , SO 2 , CO and O 3 ) and daily outpatient visits for pediatric AD in 66 hospitals, covering all districts in Shanghai, China. The over-dispersed Poisson generalized additive model (GAM) was applied to fit the associations of criteria air pollutants with hospital visits. Two-pollutant models were fitted and stratified analyses by sex, age and season were conducted. We identified 477,833 outpatient visits for pediatric AD. Each interquartile range (IQR) increase in PM 2.5 (IQR: 30.9 μg/m 3 ), PM 10 (8.9 μg/m 3 ), NO 2 (25.5 μg/m 3 ), SO 2 (5.8 μg/m 3 ) and CO (0.283 mg/m 3 ) on the concurrent day was significantly associated with increments of 2.08 % (95 % CI: 0.53 %, 3.65 %), 2.53 % (95 % CI: 0.87 %, 4.22 %), 8.14 % (95 % CI: 6.24 %, 10.08 %), 5.67 % (95 % CI: 3.58 %, 7.80 %), and 2.27 % (95 % CI: 0.70 %, 3.87 %) in pediatric AD outpatient visits, respectively. The effects of NO 2 remained robust after adjustment for other air pollutants. The exposure-response curves for PM 2.5 and PM 10 were steeper for moderate-lower concentrations, with a flatten curves at high concentration; nearly linear relationships were found for NO 2 . Higher associations of NO 2 exposure on A...