Association of hemoglobin-to-red blood cell distribution width ratio and bone mineral density in older adults

作者：Yongchun Xiao, Huawen Pan, Ruihua Huang, Ping Wu, Cheng Peng, Jianxian Luo, Jianxiong Wu, Zhifeng Wang, Hongsheng Lin, Junze Liang, Zhisheng Ji · 发表于：BMC Musculoskeletal Disorders · 年份：2024 · DOI：10.1186/s12891-024-07984-z · 被引用次数：10 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Parathyroid Disorders and Treatments、Nutrition and Health in Aging

BACKGROUND: Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) represents novel prognostic markers for diseases. However, there remains a lack of systematic research into the relationship between HRR and Bone Mineral Density (BMD) or osteoporosis in older adults. METHODS: This study utilized information from the NHANES database, selecting individuals over 50 years of age with complete femoral DXA scans and full blood counts. The relationship between HRR and femoral BMD was investigated using weighted linear models and restricted cubic spline (RCS) models. Moreover, the association between HRR and osteoporosis was further explored using logistic regression models and RCS models, with subgroup analysis conducted to test the robustness of the results. RESULTS: This study included a total of 7,149 participants, and the BMD of the group with higher HRR was significantly greater than that of the group with lower HRR. Weighted linear regression analysis found a linear positive correlation between HRR and femoral BMD. When HRR was converted from a continuous variable to a categorical variable, this relationship remained stable. In addition, multivariate logistic regression analysis showed that for each 1-unit increase in HRR, the prevalence of osteoporosis significantly decreased (OR = 0.25, 95% CI: 0.12-0.51), further confirming the findings of this study. Subgroup analysis showed that this association was not significantly affected by confounding factors across different populat...