Neoadjuvant Chemotherapy With the Angiogenesis Inhibitor Bevacizumab for Locally Advanced Cervical Cancer

作者：Sunhwa Baek, Ka‐Won Noh, Yue Zhao, Birgid Schoemig-Markiefka, Dominik Ratiu, Christian M. Domroese, Michael R. Mallmann, Peter Mallmann, Henryk Pilch · 发表于：In Vivo · 年份：2024 · DOI：10.21873/invivo.13791 · 被引用次数：2 · 研究领域：Endometrial and Cervical Cancer Treatments、Colorectal and Anal Carcinomas、Angiogenesis and VEGF in Cancer

BACKGROUND/AIM: We hypothesized that adding bevacizumab to platinum-based neoadjuvant chemotherapy - whose efficacy for patients with recurrent or metastatic cervical cancer has already been proven - could optimize the therapy regimen, leading to improved response rates and survival outcomes. PATIENTS AND METHODS: Forty patients with histologically confirmed cervical cancer with FIGO stage IB3-IVA who received platinum-based neoadjuvant treatment between March 2008 and January 2019 in the Department of Obstetrics and Gynecology of University Hospital Cologne were analyzed. Twenty patients were treated with additional bevacizumab. The comparative cohort consisted of 18 patients treated with neoadjuvant chemotherapy alone. The response rates and clinical outcomes, including progression-free survival and overall survival, were evaluated. RESULTS: Neoadjuvant chemotherapy combined with bevacizumab significantly improved the response rate (p=0.046). The survival analysis showed that patients treated without bevacizumab had better progression-free survival up to FIGO stage IVA than patients treated with bevacizumab. However, overall survival was similar for both cohorts. For patients with advanced tumor stage, including FIGO IVB, progression-free survival and overall survival improved with the addition of bevacizumab. Pathological complete remission was a statistically significant prognostic factor for progression-free survival (p=0.039) but did not significantly affect overall sur...