Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer

作者：Ding Wen, Jing Feng, Ruiping Deng, Kai Li, Hongjie Zhang · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-53488-8 · 被引用次数：44 · 研究领域：Nanoplatforms for cancer theranostics、Catalytic Processes in Materials Science、Extracellular vesicles in disease

Sonodynamic therapy (SDT) as a non-invasive antitumor strategy has been widely concerned. However, the rapid electron (e-) and hole (h+) recombination of traditional inorganic semiconductor sonosensitizers under ultrasonic (US) stimulation greatly limits the production of reactive oxygen species (ROS). Herein, we report a unique Zn/Pt dual-site single-atom driven difunctional superimposition-augmented TiO2-based sonosensitizer (Zn/Pt SATs). Initially, we verify through theoretical calculation that the strongly coupled Zn and Pt atoms can assist electron excitation at the atomic level by increasing electron conductivity and excitation efficiency under US, respectively, thus effectively improving the yield of ROS. Additionally, Zn/Pt SATs can significantly enhance ferroptosis by producing more ROS and sonoexcited holes under US stimuli. Therefore, the establishment of dual-site single-atom system represents an innovative strategy to enhance SDT in cancer model of female mice and provides a typical example for the development of inorganic sonosensitizer in the field of antitumor therapy. Sonodynamic therapy is an emerging non-invasive antitumor strategy, but its efficiency is limited by the rapid electron and hole recombination of traditional semiconductor sonosensitizers under ultrasonic stimulation. Here, the authors address this issue by developing a Zn/Pt dual-site single-atom driven difunctional superimposition-augmented TiO2-based sonosensitizer.