Syncing the brain’s networks: dynamic functional connectivity shifts from temporal interference

作者：Zhiqiang Zhu, Dongsheng Tang, Lang Qin, Zhenyu Qian, Jie Zhuang, Yu Liu · 发表于：Frontiers in Human Neuroscience · 年份：2024 · DOI：10.3389/fnhum.2024.1453638 · 被引用次数：9 · 研究领域：Transcranial Magnetic Stimulation Studies、Functional Brain Connectivity Studies、EEG and Brain-Computer Interfaces

Background Temporal interference (TI) stimulation, an innovative non-invasive brain stimulation approach, has the potential to activate neurons in deep brain regions. However, the dynamic mechanisms underlying its neuromodulatory effects are not fully understood. This study aims to investigate the effects of TI stimulation on dynamic functional connectivity (dFC) in the motor cortex. Methods 40 healthy adults underwent both TI and tDCS in a double-blind, randomized crossover design, with sessions separated by at least 48 h. The total stimulation intensity of TI is 4 mA, with each channel’s intensity set at 2 mA and a 20 Hz frequency difference (2 kHz and 2.02 kHz). The tDCS stimulation intensity is 2 mA. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected before, during, and after stimulation. dFC was calculated using the left primary motor cortex (M1) as the region of interest (ROI) and analyzed using a sliding time-window method. A two-way repeated measures ANOVA (group × time) was conducted to evaluate the effects of TI and tDCS on changes in dFC. Results For CV of dFC, significant main effects of stimulation type ( P = 0.004) and time ( P < 0.001) were observed. TI showed lower CV of dFC than tDCS in the left postcentral gyrus ( P < 0.001). TI-T2 displayed lower CV of dFC than TI-T1 in the left precentral gyrus ( P < 0.001). For mean dFC, a significant main effect of time was found ( P < 0.001). TI–T2 showed higher...