Photobiomodulation as a Potential Treatment for Alzheimer’s Disease: A Review Paper

作者：Miaomiao Wang, Deeba Dinarvand, Clement T. Y. Chan, Anatol Bragin, Lin Li · 发表于：Brain Sciences · 年份：2024 · DOI：10.3390/brainsci14111064 · 被引用次数：12 · 研究领域：Laser Applications in Dentistry and Medicine、Photoreceptor and optogenetics research、Planarian Biology and Electrostimulation

BACKGROUND: Alzheimer's disease (AD), the most prevalent form of dementia, is a leading neurodegenerative disorder currently affecting approximately 55 million individuals globally, a number projected to escalate to 139 million by 2050. Despite extensive research spanning several decades, the cure for AD remains at a developing stage. The only existing therapeutic options are limited to symptom management, and are often accompanied by adverse side effects. The pathological features of AD, including the accumulation of beta-amyloid plaques and tau protein tangles, result in progressive neuronal death, synaptic loss, and brain atrophy, leading to significant cognitive decline and a marked reduction in quality of life. OBJECTIVE: In light of the shortcomings of existing pharmacological interventions, this review explores the potential of photobiomodulation (PBM) as a non-invasive therapeutic option for AD. PBM employs infrared light to facilitate cellular repair and regeneration, focusing on addressing the disease's underlying biomechanical mechanisms. METHOD: This paper presents a comprehensive introduction to the mechanisms of PBM and an analysis of preclinical studies evaluating its impact on cellular health, cognitive function, and disease progression in AD.The review provides a comprehensive overview of the various wavelengths and application methods, evaluating their efficacy in mitigating AD-related symptoms. CONCLUSIONS: The findings underscore the significant potential ...