Ketone Skeletal Modification via a Metallaphotoredox-Catalyzed Deacylation and Acylation Strategy

作者：Ke‐Han He, Na Jin, J. Paul Chen, You-Fen Zheng, Fei Pan · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c03456 · 被引用次数：14 · 研究领域：Click Chemistry and Applications、Chemical Synthesis and Analysis、Fluorine in Organic Chemistry

Herein, we describe a dual catalytic strategy that employs dihydroquinazolinones, derived from ketone analogs, as versatile intermediates for acylation via α C-C cleavage with 2-pyridyl esters, facilitating the efficient synthesis of a variety of ketones. The reaction accommodates a wide range of ketones and carboxylic acids, showing tolerance to various functional groups. The versatility of this synthetic technique is further highlighted through its application in the late-stage modification of pharmaceuticals and biologically active natural products.