Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults

作者：Ting Zhou, Bingyu Zhang, Dazheng Zhang, Qiong Wu, Jiajie Chen, Lu Li, Yiwen Lu, Michael J. Becich, Saul Blecker, Nymisha Chilukuri, Elizabeth A. Chrischilles, Haitao Chu, Leonor Corsino, Carol Geary, Mady Hornig, Maxwell M. Hornig-Rohan, Susan Kim, David Liebovitz, Vitaly Lorman, Chongliang Luo, Hiroki Morizono, Abu Saleh Mohammad Mosa, Nathan M. Pajor, Suchitra Rao, Hanieh Razzaghi, Srinivasan Suresh, Yacob G. Tedla, Leah Vance Utset, Youfa Wang, David A. Williams, Margot Gage Witvliet, Caren Mangarelli, Ravi Jhaveri, Christopher R. Forrest, Yong Chen · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.41970 · 被引用次数：19 · 研究领域：Long-Term Effects of COVID-19、COVID-19 Clinical Research Studies、Kawasaki Disease and Coronary Complications

Importance: Obesity is associated with increased severity of COVID-19. Whether obesity is associated with an increased risk of post-acute sequelae of SARS-CoV-2 infection (PASC) among pediatric populations, independent of its association with acute infection severity, is unclear. Objective: To quantify the association of body mass index (BMI) status before SARS-CoV-2 infection with pediatric PASC risk, controlling for acute infection severity. Design, Setting, and Participants: This retrospective cohort study occurred at 26 US children's hospitals from March 2020 to May 2023 with a minimum follow-up of 179 days. Eligible participants included children and young adults aged 5 to 20 years with SARS-CoV-2 infection. Data analysis was conducted from October 2023 to January 2024. Exposures: BMI status assessed within 18 months before infection; the measure closest to the index date was selected. The BMI categories included healthy weight (≥5th to <85th percentile for those aged 5-19 years or ≥18.5 to <25 for those aged >19 years), overweight (≥85th to <95th percentile for those aged 5-19 years or ≥25 to <30 for for those aged >19 years), obesity (≥95th percentile to <120% of the 95th percentile for for those aged 5-19 years or ≥30 to <40 for those aged >19 years), and severe obesity (≥120% of the 95th percentile for those aged 5-19 years or ≥40 for those aged >19 years). Main Outcomes And Measures: To identify PASC, a diagnostic code specific for post-COVID-19 conditions was used ...