Prognostic impact of systemic immune-inflammation index in patients with acute decompensated heart failure with preserved ejection fraction -PURSUIT-HFpEF Registry-

作者：Yuki Kokubu, T Watanabe, T Yamada, Michio Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Y Nakagawa, Y Yasumura, Yohei Sotomi, Kazuo Okada, Shungo Hikoso, Daisaku Nakatani, Masatake Fukunami, Y Sakata · 发表于：European Heart Journal · 年份：2024 · DOI：10.1093/eurheartj/ehae666.1203 · 被引用次数：2 · 研究领域：Cardiac, Anesthesia and Surgical Outcomes、Inflammatory Biomarkers in Disease Prognosis、Heart Failure Treatment and Management

Abstract Background Systemic inflammation has been implicated in the pathophysiology of heart failure with preserved ejection fraction. Several studies have shown that systemic immune-inflammation index (SII), a novel index based on platelets, neutrophils, and lymphocytes, predicts poor prognosis in patients with cardiovascular disease. However, it remains to be elucidated whether SII could have predictive value in patients with acute decompensated heart failure with preserved ejection fraction (ADHF-HFpEF). Purpose This study is designed to investigate the association of SII at admission or discharge with poor clinical outcome in patients with ADHF-HFpEF. Methods Patients’ data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study, which is a prospective multicenter observational registry for ADHF-HFpEF in a city. Laboratory data and body weight measurements were performed just before discharge. We analyzed 966 patients (mean age: 81 years old, male: 45%) after exclusion of patients on dialysis, missing follow-up data, or missing data to calculate SII. SII was calculated as follows: SII = platelet count × neutrophil count / lymphocyte count on admission and at discharge. The primary endpoint was the composite of all-cause death and rehospitalization for worsening heart failure. Results During a mean follow-up period of 1.8±1.3 years, the primary endpoint was observed in 435 pa...