MOF‐Enhanced Phototherapeutic Wound Dressings Against Drug‐Resistant Bacteria

作者：Zhihao Yu, Xiali Fu, Theotim Lucas, Heng Zhao, Changchong Chen, Iharilalao Dubail, Yong Chen, G. Patriarche, Jérôme Gâteau, Florence Gazeau, Anne Jamet, Mathilde Lepoitevin, Christian Serre · 发表于：Advanced Healthcare Materials · 年份：2024 · DOI：10.1002/adhm.202402418 · 被引用次数：12 · 研究领域：Nanoplatforms for cancer theranostics、Scientific and Engineering Research Topics、Antimicrobial agents and applications

Phototherapy is a low-risk alternative to traditional antibiotics against drug-resistant bacterial infections. However, optimizing phototherapy agents, refining treatment conditions, and addressing misuse of agents, remain a formidable challenge. This study introduces a novel concept leveraging the unique customizability of metal-organic frameworks (MOFs) to house size-matched dye molecules in "single rooms". The mesoporous iron(III) carboxylate nanoMOF, MIL-100(Fe), and the hydrophobic heptamethine cyanine photothermal dye (Cy7), IR775, are selected as model systems. Their combination is predicted to minimize dye-dye interactions, leading to exceptional photostability and efficient light-to-heat conversion. Furthermore, MIL-100(Fe) preserves the antimicrobial nature of hydrophobic IR775, enabling it to disrupt bacterial cell envelopes. Through electrospinning, MIL-100(Fe)@IR775 nanoparticles are shaped into a gelatin-based film dressing for the treatment of skin wounds infected by Methicillin-resistant Staphylococcus aureus (MRSA). Activation of the dressing requires only a portable near-infrared light-emitting diode (NIR LED) and induces both low-dose photodynamic therapy (LPDT) and mild-temperature photothermal therapy (MPTT). Combined with the antimicrobial properties of IR775 and ferroptosis-like lipid peroxidation induced by MIL-100(Fe), the photoactive dressing eradicates MRSA and the healing is as quick as the uninfected wounds. This safe, cost-effective, and multifun...