Weight status change during four years and left ventricular hypertrophy in Chinese children

作者：Qin Liu, Cheng Li, Lili Yang, Zhuo Gong, Min Zhao, Pascal Bovet, Bo Xi · 发表于：Frontiers in Pediatrics · 年份：2024 · DOI：10.3389/fped.2024.1371286 · 被引用次数：39 · 研究领域：Obesity, Physical Activity, Diet、Blood Pressure and Hypertension Studies、Birth, Development, and Health

Objective It is well-established that overweight/obesity is a major risk factor for left ventricular hypertrophy (LVH) in childhood. However, it is still unclear if reversing from overweight/obesity to normal weight is associated with decreased LVH in children. This study aimed to examine the association between weight status change during four years and LVH among Chinese children based on a prospective cohort study. Methods Data were obtained from the Huantai Childhood Cardiovascular Health Cohort Study in China. A total of 1,178 children without LVH at baseline (mean age: 8.3 years) were included in this study. According to weight status [normal weight or overweight (including obesity)] at baseline (2017) and follow-up (2021), children were divided, based on sex- and age-adjusted body mass index (BMI), into four groups: persistent normal weight (normal weight at both baseline and follow-up), incident overweight (normal weight at baseline but overweight at follow-up), reversal to normal weight (overweight at baseline but normal weight at follow-up), persistent overweight (overweight at both baseline and follow-up). Results After adjustment for potential confounding factors, children with incident overweight ( n = 114, 30.63 ± 4.74 g/m 2.7 ) and those with persistent overweight ( n = 363, 31.56 ± 6.24 g/m 2.7 ) had higher left ventricular mass index (LVMI) at the end of the follow-up period than those with persistent normal weight ( n = 632, 28.46 ± 7.64 g/m 2.7 ), while thos...