Association between visceral lipid accumulation indicators and gallstones: a cross-sectional study based on NHANES 2017–2020

作者：Wenxuan Wu, Yu‐Chen Pei, Junlong Wang, Qizhi Liang, Wei Chen · 发表于：Lipids in Health and Disease · 年份：2024 · DOI：10.1186/s12944-024-02319-2 · 被引用次数：21 · 研究领域：Gallbladder and Bile Duct Disorders、Pancreatitis Pathology and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Obesity is a major contributing factor to the formation of gallstones. As early identification typically results in improved outcomes, we explored the relationship between visceral lipid accumulation indicators and the occurrence of gallstones. METHODS: This cross-sectional study involved 3,224 adults. The researchers employed multivariable logistic regression, smoothed curve fitting (SCF), threshold effects analysis, and subgroup analysis to examine the relationship between metabolic scores for visceral fat (METS-VF), waist circumference (WC), lipid accumulation products (LAP), and visceral adiposity index (VAI) and gallstones. A Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was used to identify key factors which were then used in the construction of a nomogram model. The diagnostic efficacy of this model in detecting gallstones was then determined using receiver operating characteristic curves. RESULTS: Visceral lipid accumulation indicators were strongly linked to the likelihood of having gallstones. Specific saturation effects for METS-VF, WC, LAP, and VAI and gallstones were determined using SCF. The inflection points for these effects were found to be 8.565, 108.400, 18.056, and 1.071, respectively. Subgroup analyses showed that associations remained consistent in most subgroups. The nomogram model, which was developed using critical features identified by LASSO regression, demonstrated excellent discriminatory ability, as indic...