Distributed parameter model of dynamic contrast-enhanced MRI in the identification of IDH mutation, 1p19q codeletion, and tumor cell proliferation in glioma patients

作者：Kai Zhao, Huiyu Huang, Eryuan Gao, Jinbo Qi, Ting Chen, Gaoyang Zhao, Guohua Zhao, Yu Zhang, Peipei Wang, Jie Bai, Yong Zhang, Zujun Hou, Jingliang Cheng, Xiaoyue Ma · 发表于：Frontiers in Oncology · 年份：2024 · DOI：10.3389/fonc.2024.1333798 · 被引用次数：7 · 研究领域：Glioma Diagnosis and Treatment、MRI in cancer diagnosis、Radiomics and Machine Learning in Medical Imaging

Objectives To investigate the clinical value of hemodynamic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) in predicting glioma genotypes including isocitrate dehydrogenase ( IDH ) mutation, 1p/19q codeletion status and the tumor proliferation index ( Ki-67 ) noninvasively. And to compare the diagnostic performance of parameters of distributed parameter (DP)model and extended Tofts (Ex-Tofts) model. Materials and methods Dynamic contrast-enhanced MRI (DCE-MRI) data of patients with glioma were prospectively enrolled from April 2021 to May 2023. The imaging data were analyzed using DP and Ex-Tofts model for evaluating the perfusion and permeability characteristics of glioma. Comparisons were performed according to IDH genotype in all glioma patients and 1p/19q codeletion in IDH mutation glioma patients. Receiver operating characteristic (ROC) curves were generated for DCE-MRI parameters. The Spearman rank correlation coefficients were calculated between DCE MRI parameters and Ki-67 index. Results In IDH -mutation gliomas, a higher blood flow (F) was found in 1p/19q codeletion gliomas than in 1p/19q intact gliomas. No parameter derived from Ex-Tofts model showed significant differences in predicting 1p/19q status. Fractional volume of interstitial space ( V e ) derived from both the DP and Ex-Tofts models exhibited optimal performance in predicting IDH genotype (AUC = 0.818, 0.828, respectively). V e also showed the highest correlations with Ki-67 LI within the...