Pathogenic Characteristics of Five Different Lineage of Korean PRRSV‐2 Isolates (NADC30‐Like, VR2332‐Like, LKA, LKB, and LKC)

作者：Chang‐Gi Jeong, Seung-Chai Kim, Simin Lee, Hwan-Ju Kim, Sameer ul Salam Mattoo, Salik Nazki, Amina Khatun, Go-Eun Shin, Myeon‐Sik Yang, Hye-Young Jeoung, Kyoung-Ki Lee, Jae‐Ku Oem, Sang‐Myeong Lee, Bumseok Kim, Gayeon Won, Won‐Il Kim · 发表于：Transboundary and Emerging Diseases · 年份：2024 · DOI：10.1155/2024/1618472 · 被引用次数：10 · 研究领域：Animal Virus Infections Studies、Viral gastroenteritis research and epidemiology、Virus-based gene therapy research

Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen in the worldwide swine industry. The virus shows high genetic variation coupled with a broad range of virulence in pigs. Although multiple lineages of the virus have been prevalent throughout in Korea, the characteristics of lineage-wise pathogenicity are largely unknown. Therefore, this study was designed to analyze and compare the pathogenicity of 11 representative Korean PRRSV-2 isolates selected from PRRSV-2 lineages circulating in Korea, NADC30-like, VR2332-like, and three nation-specific lineages (lineage KOR A (LKA), lineage KOR B (LKB), and lineage KOR C (LKC)), which have been continuously prevalent in the nation. Eleven groups of pigs were experimentally infected with one Korean PRRSV-2 isolate through four consecutive animal experiments. Body weight and body temperature were recorded during each 4-week challenge experiment period, and virological, serological, and histopathological tests were performed on the collected samples. The data from the animal experiments were integrated into two indicators-excretion and clinical signs-through correlation and principal component analysis (PCA). Meta-analysis was used to compare PRRSV-2 isolates using each indicator. Based on these analyses, while L1C viruses used in this study (JB15-N-P31-GB and JB15-N-PJ73-GN, similar to NADC30-like strains) exhibited low or moderate levels of excretion and clinical signs, lineage 5 (L5) or modified live...