The Influence of Material Properties and Wall Thickness on Predicted Wall Stress in Ascending Aortic Aneurysms: A Finite Element Study

作者：Yu Zhu, Selene Pirola, M. Yousuf Salmasi, Sumesh Sasidharan, Serena M. Fisichella, Declan P. O’Regan, James E. Moore, Thanos Athanasiou, Xiao Yun Xu · 发表于：Cardiovascular Engineering and Technology · 年份：2024 · DOI：10.1007/s13239-024-00756-9 · 被引用次数：8 · 研究领域：Aortic aneurysm repair treatments、Aortic Disease and Treatment Approaches、Elasticity and Material Modeling

PURPOSE: Finite element analysis (FEA) has been used to predict wall stress in ascending thoracic aortic aneurysm (ATAA) in order to evaluate risk of dissection or rupture. Patient-specific FEA requires detailed information on ATAA geometry, loading conditions, material properties, and wall thickness. Unfortunately, measuring aortic wall thickness and mechanical properties non-invasively poses a significant challenge, necessitating the use of non-patient-specific data in most FE simulations. This study aimed to assess the impact of employing non-patient-specific material properties and wall thickness on ATAA wall stress predictions. METHODS: FE simulations were performed on 13 ATAA geometries reconstructed from computed tomography angiography (CTA) images. Patient-specific material properties and wall thicknesses were made available from a previous study where uniaxial tensile testing was performed on tissue samples obtained from the same patients. The ATAA wall models were discretised with hexahedral elements and prestressed. For each ATAA model, FE simulations were conducted using patient-specific material properties and wall thicknesses, and group-mean values derived from all tissue samples included in the same experimental study. Literature-based material property and wall thickness were also obtained from the literature and applied to 4 representative cases. Additional FE simulations were performed on these 4 cases by employing group-mean and literature-based wall thickn...