Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process

作者：Yun-Xuan Luo, Jie Huang, Guojiao Wu, Xiang‐Ying Tang, Jinping Qu · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-53635-1 · 被引用次数：22 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions

Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C–O, C–S, and C–N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules. Visible-light photochemistry, which includes energy transfer processes, can enable transformations that are difficult or prohibited from thermal pathways. Here, the authors develop a deoxygenative coupling of 1,2-dicarbonyl compounds with a variety of nucleophiles via energy transfer.