Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management

作者：Xu Chen, Jiapan Shen, Xueqin Jiang, Min Pan, Shuang Chang, Juanjuan Li, Lei Wang, Manli Miao, Xiaoxia Feng, Ling Zhang, Guoqing Shu, Wenjian Liu, Fangzhou Xu, Wentao Zhang, Zhao Ding, Huaiyuan Zong, Weiwei Liu, Dapeng Li, Biao Chen, Min Shao, Guanghe Fei, Xiaojun Zha, Xiaoyun Fan · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.102318 · 被引用次数：31 · 研究领域：Ferroptosis and cancer prognosis、MicroRNA in disease regulation、Circular RNAs in diseases

: These findings provide compelling evidence that DIPY inhibits ferroptosis in pulmonary epithelial and endothelial cells by modulating the SOD1/CREB1/HMOX1 signaling axis and suggest DIPY as a promising therapeutic strategy for ARDS treatment.