HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages

作者：Shulin Zhao, Rongrong Zhao, Chuanzheng Wang, Caizhi Ma, Zijie Gao, Boyan Li, Yanhua Qi, Wei Qiu, Ziwen Pan, Shaobo Wang, Qindong Guo, Jiawei Qiu, Yang Fan, Xiaofan Guo, Hao Xue, Lin Deng, Gang Li · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.100939 · 被引用次数：28 · 研究领域：Histone Deacetylase Inhibitors Research、Cancer-related gene regulation、Peptidase Inhibition and Analysis

Our findings revealed the role of the novel HDAC7-H3K27ac-SOX8/JUN-LGALS3-ITGB1 axis in maintaining the crosstalk between MES GBM and M2 MDM, highlighting that HDAC7 and LGALS3 may serve as potential prognostic biomarkers and therapeutic targets in GBM.